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Frarbeiten forms Registration forms Randomisation forms Administration of chemotherapy Documentation of chemotherapy Documentation of radiotherapy Histopathology forms Common Toxicity Criteria CTC Report of serious adverse events SAE Follow-up forms List of participating centers Due to unsatisfactory progression free survival data in LGG this combination needs to be strengthened to improve outcome. The original paraffin block if possible The pathology report from the originating hospital, along with patient erarbriten including the age of the patient and site of biopsy.

Data exist on a small cohort of children which seems to indicate that the LI may be prognostically significant as well as the loss of 17p PradosWillert However, some recommendations may be useful to define the role of surgery within the treatment concept.

Since a first attempt of resection should be performed, if feasible, while some children will be diagnosed on neuroradiological grounds only, there are three major settings, where the decision to start non-surgical therapy has to be made. Two or more neurofibromas of any type or one plexiform neurofibroma Freckling in the axillary or inguinal region. The national center will check the eligibility of the patient and then obtain central randomization. Concomittant medication was variable.


Distribution of clinical characteristics: Strategies are adopted to consider the specific conditions for tumor location in the spinal canal, cerebral hemispheres, cerebellum or caudal brain stem. Spinal contrast enhanced MRI, ven previously pathologic at the same time points as 4. All eligible patients without Neurofibromatosis NF I receiving chemotherapy as their first non-surgical therapy are eligible for randomization.

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Children still in the young age group, in whom radiotherapy should be further postponed, should receive second line chemotherapy. Median time to progression was 27 months range months.

DS is usually due to a low grade glioma involving the hypothalamus. There are certainly inconsistencies between studies with regard to NF status and eligibility criteria for enrollment.

If necessary, they can be added after the T1-weighted post-contrast MRI has been acquired, without problems associated with artefacts. James Zahlsnraum, Edinburgh France: Thus changes for the newly defined patient subgroups are the following: The CHQ is available zahlenrqum multiple European languages and should be adopted by other participating countries data is only by parental proxy response.

Focal radiotherapy follows general guidelines. However, the precise definition of monomorphous pilomyxoid pattern is still a matter of discussion. In young children confrontation testing using a toy or bright object and two examiners is a better technique.


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Perhaps there is a reactive metabolite, activated by leucocytes, with infection or inflammation as risk factors for its release Utrecht. CSF sampling to be performed only in case of disseminated disease and if previously positive 7. Similarly, in the CCSG experience no difference in zahlenrau of 3-year PFS was documented between patients who had a major response and the ones who had just a minor response or stable disease: However, it should be 100 that tumor volume reduction may have a beneficial effect on severe neurologic symptoms at presentation, especially diencephalic syndrome DS.

Qualitative changes of contrast enhancement will be described and correlated with response.

Dies man entweder auf der Kartei mit Folienstift oder im Heft erledigen. Germany 90, Italy 47, United Kingdom 59, Others 8.

SIOP – LGG Cooperative multicenter Study for Children and |

Later only, if indicated. Statistical analysis will be only descriptive. In the previous study the age of 5 years was empirically chosen as the cut-off age for recommending chemotherapy or radiotherapy as non-surgical therapy for symptomatic or progressive tumors.

National brain tumor reference centers: Neuroradiologic criteria have to be fulfilled for all children not biopsied and central neuroradiologic review has to be obtained.